Ca. 1612

Santorio Santorio attempts first measurement of human temperature with a thermoscope with a calibrated tube. “At the end of the sealed tube, he had a bulb blown of the optimal size to be inserted in the mouth. The open end was submersed in fluid. As the air expanded due to the oral temperature, fluid was expelled from the tube. After a fixed period of time, the bulb was removed, the air cooled, causing the fluid to rise in the calibrated tube” (Grodzinsky & Sund Levander).