1820

First publication of Pharmacopoeia of the United States of America (USP), followed by publication of the United States Dispensatory (commentary on USP) in 1833 (Higby, 81-83). After 1865, “pharmacists turned more and more to wholesalers for their prescription ingredients and less to their own laboratories. . . .”Antagonism between the small-scale practitioners who wrote the standards and the large-scale manufacturers who made most drug preparations reduced the effectiveness of the Pharmacopoeia during the 1860s and 1870s (95).