1859

Publication of Alfred Garrod’s The Nature and Treatment of Gout and Rheumatic Gout, in which he differentiated patients with gout from patients with arthritis rheumatoid. Here he introduced the term “arthritis rheumatoid,” i.e., rheumatoid arthritis, rejecting terms like “chronic rheumatism” (Herberden) and “rheumatic gout” (Fuller), in order to differentiate the disease from gout and rheumatism. Rheumatoid arthritis was characterized by its difficult control and disabling clinical course (Iglesias, et al.; Hickman).