1940

Linus Pauling’s advance in instructional theory of antibody formation, whereby “Antigen would serve as the template for the final step of protein formation in which the coiling of the nascent polypeptide chain of the antibody molecule would conform more or less precisely to the template offered by the surface determinant of the antigen molecule. Once the appropriate configuration had been attained, it would be stabilized by familiar interatomic bonds and thus satisfy all of the requirements of specific antibody” (Silverstein, 70-71).