1957

John Crofton and colleagues at Edinburgh University initiate huge international trial that demonstrated that with adequate triple-drug therapy (streptomycin, PAC, isoniazid), TB was 100% curable (F. Ryan, 381). In 60s, Rifamipicin (discovered 1963) replaced streptomycin and ethambutol (discovered 1967) replaced PAS, while isoniazid remains among the three modern drugs in current triple-drug therapy (384). In U.S., number of infected TB patients fell through 50s, 60s, and 70s, before beginning a progressive rise in 1985 (390).