1958

Paul Janssen of The Janssen (pharmaceutical) Company produces molecule R1625, later known as haloperidol. It was effective with Tourette’s patients and, as a neuroleptic, more much less sedative, and worked better managing hallucinations, than chlorpromazine. It was more likely to cause extrapyramidal symptoms than chlorpromazine. It became available in U.S. only in 1965 and in the 80s was the most commonly used antipsychotic in U.S. (Healy, II, 119-24).