Ca. 2540BCE

First identification of gout (podagra, i.e., acute gout occurring in first metatarsophalangeal joint) by Egyptians. In fifth century B.C., Hippocrates referred to it as the “unwalkable disease” and linked it to an intemperate lifestyle (Nuki & Simkin). Dominican monk Randolphus of Bocking, domestic chaplain to the Bishop of Chichester (loc 1197–1258), was first to use the word “gout” to describe podagra. It derived from Latin word gutta (drop), which referred to the belief that an excess of one of the four humors had dropped or flowed into a joint (Coperman).